GRAP

GRB2-related adapter protein is a protein that in humans is encoded by the GRAP gene.^[5][6][7]

GRAP
Identifiers
Aliases	GRAP, GRB2-related adaptor protein, GRB2 related adaptor protein, DFNB114
External IDs	OMIM: 604330; MGI: 1918770; HomoloGene: 4822; GeneCards: GRAP; OMA:GRAP - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p11.2 Start 19,020,656 bp[1] End 19,047,011 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B2 Start 61,544,091 bp[2] End 61,563,610 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen granulocyte lymph node blood right lung upper lobe of left lung gallbladder apex of heart appendix right lobe of thyroid gland Top expressed in mesenteric lymph nodes thymus spleen right lung lobe blood lip subcutaneous adipose tissue embryo left lung lobe right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding non-membrane spanning protein tyrosine kinase activity signaling receptor binding Cellular component cytoplasm cytosol extrinsic component of cytoplasmic side of plasma membrane Biological process cell-cell signaling Ras protein signal transduction positive regulation of signal transduction transmembrane receptor protein tyrosine kinase signaling pathway cell migration cell differentiation peptidyl-tyrosine autophosphorylation regulation of cell population proliferation innate immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10750 71520 Ensembl ENSG00000154016 ENSMUSG00000004837 UniProt Q13588 Q9CX99 RefSeq (mRNA) NM_006613 NM_001330148 NM_027817 RefSeq (protein) NP_001317077 NP_006604 NP_082093 Location (UCSC) Chr 17: 19.02 – 19.05 Mb Chr 11: 61.54 – 61.56 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the GRB2/Sem5 (C. elegans homolog)/Drk (Drosophila homolog) family. This member functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain.^[7]

Interactions

GRAP has been shown to interact with Linker of activated T cells.^[8][9]