GRB10

Growth factor receptor-bound protein 10 also known as insulin receptor-binding protein Grb-IR is a protein that in humans is encoded by the GRB10 gene.^[5][6][7][8]

GRB10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3HK0, 1NRV
Identifiers
Aliases	GRB10, GRB-IR, Grb-10, IRBP, MEG1, RSS, growth factor receptor bound protein 10
External IDs	OMIM: 601523; MGI: 103232; HomoloGene: 3882; GeneCards: GRB10; OMA:GRB10 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p12.1 Start 50,590,063 bp[1] End 50,793,462 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A1|11 7.15 cM Start 11,880,508 bp[2] End 11,988,683 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas pars compacta visceral pleura Brodmann area 23 pars reticulata endothelial cell dorsal motor nucleus of vagus nerve middle temporal gyrus pancreatic ductal cell Epithelium of choroid plexus Top expressed in mandibular prominence endocardial cushion atrium maxillary prominence atrioventricular valve Gonadal ridge abdominal wall ureter primitive streak dermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding insulin receptor binding identical protein binding Cellular component cytoplasm cytosol plasma membrane protein-containing complex Biological process response to insulin positive regulation of vascular endothelial growth factor receptor signaling pathway negative regulation of glucose import negative regulation of insulin receptor signaling pathway insulin-like growth factor receptor signaling pathway negative regulation of phosphorylation positive regulation of phosphorylation negative regulation of glycogen biosynthetic process signal transduction insulin receptor signaling pathway axon guidance negative regulation of Wnt signaling pathway positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2887 14783 Ensembl ENSG00000106070 ENSMUSG00000020176 UniProt Q13322 Q60760 RefSeq (mRNA) NM_001001549 NM_001001550 NM_001001555 NM_005311 NM_001350814 NM_001350815 NM_001350816 NM_001371008 NM_001371009 NM_001177629 NM_010345 NM_001370603 RefSeq (protein) NP_001001549 NP_001001550 NP_001001555 NP_001337743 NP_001337744 NP_001337745 NP_001357937 NP_001357938 NP_001171100 NP_034475 NP_001357532 Location (UCSC) Chr 7: 50.59 – 50.79 Mb Chr 11: 11.88 – 11.99 Mb PubMed search [3] [4]
Wikidata
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Function

The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors (e.g., IGF1R and IGF2R). Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified.^[5]

Animal studies

Mice whose paternally inherited Grb10 gene is inactivated are more aggressive while those whose maternally inherited allele is inactivated exhibit foetal overgrowth and are significantly bigger than wild-type litter-mates.^[9]

Interactions

GRB10 has been shown to interact with

• Abl gene,^[10][11]
• BCR gene,^[10]
• C-Raf,^[12][13]
• c-Kit,^[14]
• Insulin receptor,^{[11][15][16][17][18]}
• Insulin-like growth factor 1 receptor,^{[18][19][20][21]}
• MAP2K1,^[13] and
• RET proto-oncogene.^[22]