GREB1

Growth regulation by estrogen in breast cancer 1 is a protein that in humans is encoded by the GREB1 gene.^[5]

GREB1
Identifiers
Aliases	GREB1, growth regulation by estrogen in breast cancer 1, growth regulating estrogen receptor binding 1
External IDs	OMIM: 611736; MGI: 2149712; HomoloGene: 8780; GeneCards: GREB1; OMA:GREB1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p25.1 Start 11,482,341 bp[1] End 11,642,788 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 A1.1 Start 16,720,616 bp[2] End 16,850,887 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary right ovary germinal epithelium canal of the cervix left uterine tube myometrium body of uterus right uterine tube prostate ectocervix Top expressed in tail of embryo cumulus cell lumbar spinal ganglion efferent ductule primitive streak otic vesicle adrenal gland substantia nigra Paneth cell ovary More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 9687 268527 Ensembl ENSG00000196208 ENSMUSG00000036523 UniProt Q4ZG55 Q3UHK3 RefSeq (mRNA) NM_014668 NM_033090 NM_148903 NM_001252071 NM_015764 RefSeq (protein) NP_055483 NP_149081 NP_683701 NP_001239000 NP_056579 Location (UCSC) Chr 2: 11.48 – 11.64 Mb Chr 12: 16.72 – 16.85 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[5]