GRID1

Glutamate receptor delta-1 subunit also known as GluD1 or GluRδ1 is a transmembrane protein^[5][6] (1009 aa) encoded by the GRID1 gene.^[7][8] A C-terminal GluD1 splicing isoform (896 aa) has been described based on mRNA analysis.^[9]

GRID1
Identifiers
Aliases	GRID1, GluD1, glutamate ionotropic receptor delta type subunit 1, GluD1-b
External IDs	OMIM: 610659; MGI: 95812; HomoloGene: 69017; GeneCards: GRID1; OMA:GRID1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q23.1-q23.2 Start 85,599,552 bp[1] End 86,366,795 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 B|14 20.84 cM Start 34,542,065 bp[2] End 35,305,336 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex C1 segment nucleus accumbens putamen caudate nucleus hypothalamus substantia nigra external globus pallidus pars compacta amygdala Top expressed in Region I of hippocampus proper dentate gyrus of hippocampal formation granule cell nucleus accumbens dorsomedial hypothalamic nucleus perirhinal cortex entorhinal cortex superior frontal gyrus primary visual cortex lumbar subsegment of spinal cord substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ion channel activity extracellularly glutamate-gated ion channel activity ionotropic glutamate receptor activity glutamate receptor activity signaling receptor activity transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component integral component of membrane cell junction postsynaptic membrane plasma membrane synapse extracellular exosome membrane glutamatergic synapse integral component of postsynaptic density membrane Biological process social behavior ion transmembrane transport ionotropic glutamate receptor signaling pathway ion transport excitatory postsynaptic potential transport synaptic transmission, glutamatergic modulation of chemical synaptic transmission regulation of postsynaptic membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2894 14803 Ensembl ENSG00000182771 ENSMUSG00000041078 UniProt Q9ULK0 Q61627 RefSeq (mRNA) NM_017551 NM_008166 RefSeq (protein) NP_060021 NP_032192 Location (UCSC) Chr 10: 85.6 – 86.37 Mb Chr 14: 34.54 – 35.31 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a subunit of glutamate receptor ligand-gated ion channel. Most of these channels mediate fast excitatory synaptic transmission in the central nervous system. GluD1 is expressed in the central nervous system^[10] and is important in synaptic plasticity.^[7][11]

Clinical significance

Several genetic epidemiology studies have shown a strong association between several variants of the GRID1 gene and increased risk of developing schizophrenia.^[12][13]

See also

• GRID2