GRIK5

Glutamate receptor, ionotropic kainate 5 is a protein that in humans is encoded by the GRIK5 gene.^[5][6]

GRIK5
Identifiers
Aliases	GRIK5, EAA2, GRIK2, GluK5, KA2, glutamate ionotropic receptor kainate type subunit 5
External IDs	OMIM: 600283; MGI: 95818; HomoloGene: 1578; GeneCards: GRIK5; OMA:GRIK5 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 41,998,321 bp[1] End 42,070,206 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A3|7 13.73 cM Start 25,009,849 bp[2] End 25,072,346 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory bulb lateral nuclear group of thalamus ventral tegmental area subthalamic nucleus vena cava superior vestibular nucleus inferior ganglion of vagus nerve Pons external globus pallidus pars compacta Top expressed in superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell entorhinal cortex perirhinal cortex CA3 field neural layer of retina olfactory tubercle ventricular zone primary motor cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glutamate receptor activity PDZ domain binding kainate selective glutamate receptor activity SH3 domain binding ion channel activity ionotropic glutamate receptor activity identical protein binding extracellularly glutamate-gated ion channel activity ligand-gated ion channel activity signaling receptor activity transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component integral component of membrane perikaryon postsynaptic membrane kainate selective glutamate receptor complex membrane postsynaptic density synapse cell junction terminal bouton axon dendrite soma endoplasmic reticulum neuron projection ionotropic glutamate receptor complex presynaptic membrane nucleus plasma membrane hippocampal mossy fiber to CA3 synapse glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane integral component of postsynaptic density membrane Biological process synaptic transmission, glutamatergic regulation of membrane potential ion transport receptor clustering protein retention in ER lumen regulation of synaptic vesicle fusion to presynaptic active zone membrane ion transmembrane transport positive regulation of neuron apoptotic process establishment of localization in cell ionotropic glutamate receptor signaling pathway excitatory postsynaptic potential cellular response to glucose stimulus chemical synaptic transmission modulation of chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2901 14809 Ensembl ENSG00000105737 ENSMUSG00000003378 UniProt Q16478 Q61626 RefSeq (mRNA) NM_001301030 NM_002088 NM_008168 NM_001360067 RefSeq (protein) NP_001287959 NP_002079 NP_032194 NP_001346996 NP_001389776 NP_001389777 NP_001389778 Location (UCSC) Chr 19: 42 – 42.07 Mb Chr 7: 25.01 – 25.07 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members.^[6]

Interactions

GRIK5 has been shown to interact with DLG4^[7][8] and GRIK2.^[9][10]

See also

• Kainate receptor