GRIN3A

Glutamate [NMDA] receptor subunit 3A is a protein that in humans is encoded by the GRIN3A gene.^[5]

GRIN3A
Identifiers
Aliases	GRIN3A, GluN3A, NMDAR-L, NR3A, glutamate ionotropic receptor NMDA type subunit 3A, NMDAR3A
External IDs	OMIM: 606650; MGI: 1933206; HomoloGene: 128613; GeneCards: GRIN3A; OMA:GRIN3A - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q31.1 Start 101,569,352 bp[1] End 101,738,647 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 B1 Start 49,661,611 bp[2] End 49,845,744 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 46 middle temporal gyrus testicle Brodmann area 23 prefrontal cortex pars compacta entorhinal cortex dorsolateral prefrontal cortex cingulate gyrus anterior cingulate cortex Top expressed in phalanx of second toe subiculum habenula dorsomedial hypothalamic nucleus supraoptic nucleus anterior amygdaloid area phalanx of third toe paraventricular nucleus of hypothalamus medial dorsal nucleus pontine nuclei More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glycine binding identical protein binding protein phosphatase 2A binding ion channel activity extracellularly glutamate-gated ion channel activity calcium channel activity ionotropic glutamate receptor activity protein binding NMDA glutamate receptor activity signaling receptor activity transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component synapse integral component of membrane NMDA selective glutamate receptor complex cell junction neuron projection postsynaptic density postsynaptic membrane membrane soma plasma membrane glutamatergic synapse Biological process calcium ion transport dendrite development response to ethanol prepulse inhibition ion transport calcium ion transmembrane transport ionotropic glutamate receptor signaling pathway ion transmembrane transport excitatory postsynaptic potential signal transduction regulation of postsynaptic membrane potential regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 116443 242443 Ensembl ENSG00000198785 ENSMUSG00000039579 UniProt Q8TCU5 A2AIR5 RefSeq (mRNA) NM_133445 NM_001033351 NM_001276355 RefSeq (protein) NP_597702 NP_001028523 NP_001263284 Location (UCSC) Chr 9: 101.57 – 101.74 Mb Chr 4: 49.66 – 49.85 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a subunit of the N-methyl-D-aspartate (NMDAR) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity.^[5]

See also

• NMDA receptor