GRIPAP1

GRIP1-associated protein 1 is a protein that in humans is encoded by the GRIPAP1 gene.^[5][6]

GRIPAP1
Identifiers
Aliases	GRIPAP1, GRASP-1, GRIP1 associated protein 1
External IDs	OMIM: 300408; MGI: 1859616; HomoloGene: 41348; GeneCards: GRIPAP1; OMA:GRIPAP1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.23 Start 48,973,720 bp[1] End 49,002,264 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A1.1|X 3.51 cM Start 7,656,004 bp[2] End 7,686,806 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe sural nerve anterior pituitary cingulate gyrus anterior cingulate cortex Brodmann area 9 prefrontal cortex granulocyte Hypothalamus Top expressed in granulocyte neural layer of retina superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell cerebellar cortex yolk sac nucleus of stria terminalis ventricular zone central gray substance of midbrain More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding molecular function Cellular component endosome blood microparticle nucleoplasm cytosol intracellular membrane-bounded organelle postsynaptic recycling endosome membrane cell junction axon dendrite early endosome membrane cell projection synapse recycling endosome membrane glutamatergic synapse extrinsic component of postsynaptic early endosome membrane Biological process neurotransmitter receptor transport, endosome to postsynaptic membrane regulation of modification of synaptic structure transport protein transport biological process regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane regulation of recycling endosome localization within postsynapse Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56850 54645 Ensembl ENSG00000068400 ENSMUSG00000031153 UniProt Q4V328 Q8VD04 RefSeq (mRNA) NM_020137 NM_207672 NM_001290455 NM_207670 NM_001359289 NM_001359290 NM_001359291 NM_001359293 RefSeq (protein) NP_064522 NP_001277384 NP_997553 NP_001346218 NP_001346219 NP_001346220 NP_001346222 Location (UCSC) Chr X: 48.97 – 49 Mb Chr X: 7.66 – 7.69 Mb PubMed search [3] [4]
Wikidata
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Function

GRASP1 is a neuron-specific guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF) and is associated with the GRIP/AMPA receptor complex in brain (Ye et al., 2000).[supplied by OMIM]^[6]

Interactions

GRIPAP1 has been shown to interact with GRIP1.^[5]