GSTA2

Glutathione S-transferase A2 is an enzyme that in humans is encoded by the GSTA2 gene.^[5]

GSTA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AGS, 2VCT, 2WJU, 4ACS
Identifiers
Aliases	GSTA2, GST2, GSTA2-2, GTA2, GTH2, glutathione S-transferase alpha 2
External IDs	OMIM: 138360; MGI: 95863; HomoloGene: 47952; GeneCards: GSTA2; OMA:GSTA2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p12.2 Start 52,750,087 bp[1] End 52,763,475 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 E1|9 43.65 cM Start 78,238,300 bp[2] End 78,263,070 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas duodenum olfactory zone of nasal mucosa gallbladder islet of Langerhans liver human kidney right lobe of liver right testis left testis Top expressed in epithelium of stomach right kidney conjunctival fornix human kidney transitional epithelium of urinary bladder left lobe of liver mucous cell of stomach esophagus skin of external ear retinal pigment epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity glutathione transferase activity protein binding Cellular component cytoplasm cytosol extracellular exosome Biological process metabolism epithelial cell differentiation glutathione derivative biosynthetic process glutathione metabolic process interleukin-12-mediated signaling pathway xenobiotic metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2939 14858 Ensembl ENSG00000244067 ENSMUSG00000057933 UniProt P09210 P10648 RefSeq (mRNA) NM_000846 NM_008182 RefSeq (protein) NP_000837 NP_032208 Location (UCSC) Chr 6: 52.75 – 52.76 Mb Chr 9: 78.24 – 78.26 Mb PubMed search [3] [4]
Wikidata
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Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.^[5]