GTF2A1L

TFIIA-alpha and beta-like factor is a protein that in humans is encoded by the GTF2A1L gene.^[4][5][6][7]

GTF2A1L
Identifiers
Aliases	GTF2A1L, ALF, general transcription factor IIA subunit 1 like
External IDs	OMIM: 605358; MGI: 1919078; HomoloGene: 86732; GeneCards: GTF2A1L; OMA:GTF2A1L - orthologs
Gene location (Mouse) Chr. Chromosome 17 (mouse)[1] Band 17|17 E4 Start 88,976,088 bp[1] End 89,022,580 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium left uterine tube Achilles tendon canal of the cervix right lung popliteal artery myometrium ascending aorta left coronary artery gastric mucosa Top expressed in seminiferous tubule spermatid spermatocyte primary oocyte secondary oocyte zygote embryo embryo blastocyst medial ganglionic eminence More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding transcription coactivator activity protein binding Cellular component transcription factor TFIIA complex nucleus cytoplasm Biological process transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated transcription by RNA polymerase II cognition transcription, DNA-templated positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11036 71828 Ensembl n/a ENSMUSG00000024154 UniProt Q9UNN4 Q8R4I4 RefSeq (mRNA) NM_172196 NM_001193487 NM_006872 NM_023630 RefSeq (protein) NP_001180416 NP_006863 NP_076119 Location (UCSC) n/a Chr 17: 88.98 – 89.02 Mb PubMed search [2] [3]
Wikidata
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The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve the effects of TFIIA on the interaction between TATA-binding protein (TBP) and DNA.

This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that is able to stabilize the binding of TBP to DNA and may be uniquely important to testis biology. Alternative splicing for this locus has been observed and two variants, encoding distinct isoforms, have been identified.

Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (SALF), which encodes a fusion protein consisting of sequence sharing identity with each individual gene product.^[7]