GTPBP1

GTP-binding protein 1 is a protein that in humans is encoded by the GTPBP1 gene.^[5][6]

GTPBP1
Identifiers
Aliases	GTPBP1, GP-1, GP1, HSPC018, GTP binding protein 1
External IDs	OMIM: 602245; MGI: 109443; HomoloGene: 3165; GeneCards: GTPBP1; OMA:GTPBP1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 38,705,742 bp[1] End 38,738,299 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 79,575,046 bp[2] End 79,605,680 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve gastric mucosa ventricular zone ganglionic eminence right uterine tube left lobe of thyroid gland skin of leg popliteal artery tibial arteries left ovary Top expressed in neural layer of retina granulocyte dentate gyrus of hippocampal formation granule cell lip ventricular zone thymus secondary oocyte fetal liver hematopoietic progenitor cell zygote molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding RNA binding GTPase activity translation elongation factor activity Cellular component cytoplasm cytoplasmic exosome (RNase complex) cytosol membrane Biological process positive regulation of mRNA catabolic process immune response signal transduction GTP metabolic process translational elongation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9567 14904 Ensembl ENSG00000100226 ENSMUSG00000042535 UniProt O00178 O08582 RefSeq (mRNA) NM_004286 NM_013818 RefSeq (protein) NP_004277 NP_038846 Location (UCSC) Chr 22: 38.71 – 38.74 Mb Chr 15: 79.58 – 79.61 Mb PubMed search [3] [4]
Wikidata
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This gene is upregulated by interferon-gamma and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. A structurally similar protein has been found in mice, where disruption of the gene for that protein had no observable phenotype.^[6]