GTPBP4

Nucleolar GTP-binding protein 1 is a protein that in humans is encoded by the GTPBP4 gene.^[5][6]

GTPBP4
Identifiers
Aliases	GTPBP4, CRFG, NGB, NOG1, GTP binding protein 4
External IDs	MGI: 1916487; HomoloGene: 7100; GeneCards: GTPBP4; OMA:GTPBP4 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p15.3 Start 988,434 bp[1] End 1,019,932 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A1 Start 9,016,367 bp[2] End 9,046,119 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm epithelium of nasopharynx Achilles tendon mucosa of urinary bladder amniotic fluid cartilage tissue stromal cell of endometrium Skeletal muscle tissue of rectus abdominis right adrenal cortex gastrocnemius muscle Top expressed in otic placode saccule otic vesicle morula morula epiblast embryo blastocyst Ileal epithelium primitive streak More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding protein binding GTPase activity RNA binding Cellular component cytoplasm Golgi apparatus nuclear membrane membrane nucleolus perinuclear region of cytoplasm nucleus cytosol Biological process regulation of cyclin-dependent protein serine/threonine kinase activity ribosome biogenesis negative regulation of cell-cell adhesion protein stabilization negative regulation of DNA replication negative regulation of protein ubiquitination negative regulation of cell migration osteoblast differentiation negative regulation of collagen binding negative regulation of cell population proliferation maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23560 69237 Ensembl ENSG00000107937 ENSMUSG00000021149 UniProt Q9BZE4 Q99ME9 RefSeq (mRNA) NM_012341 NM_027000 RefSeq (protein) NP_036473 NP_081276 Location (UCSC) Chr 10: 0.99 – 1.02 Mb Chr 13: 9.02 – 9.05 Mb PubMed search [3] [4]
Wikidata
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GTPases function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G protein-coupled receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target.^[6]