GUCY1B3

Guanylate cyclase soluble subunit beta-1 is an enzyme that in humans is encoded by the GUCY1B3 gene.^[5][6]

GUCY1B1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WZ1, 3UVJ, 4NI2
Identifiers
Aliases	GUCY1B1, guanylate cyclase 1, soluble, beta 3, GUCSB3, guanylate cyclase 1 soluble subunit beta, GC-SB3, GUC1B3, GC-S-beta-1, guanylate cyclase 1 soluble subunit beta 1, GUCB3, GUCY1B3
External IDs	OMIM: 139397; MGI: 1860604; HomoloGene: 664; GeneCards: GUCY1B1; OMA:GUCY1B1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q32.1 Start 155,758,992 bp[1] End 155,807,811 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 E3 Start 81,939,313 bp[2] End 81,981,996 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus orbitofrontal cortex lateral nuclear group of thalamus superior frontal gyrus Brodmann area 46 postcentral gyrus Brodmann area 23 pars compacta pons entorhinal cortex Top expressed in olfactory tubercle habenula lateral septal nucleus anterior amygdaloid area globus pallidus left lung lobe ventromedial nucleus dorsomedial hypothalamic nucleus dorsal tegmental nucleus mammillary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding guanylate cyclase activity GTP binding metal ion binding protein binding heme binding lyase activity phosphorus-oxygen lyase activity signaling receptor activity adenylate cyclase activity Cellular component plasma membrane guanylate cyclase complex, soluble cytoplasm presynaptic active zone Biological process intracellular signal transduction cyclic nucleotide biosynthetic process blood circulation nitric oxide-cGMP-mediated signaling pathway cGMP biosynthetic process nitric oxide mediated signal transduction cellular response to nitric oxide cGMP-mediated signaling trans-synaptic signaling by nitric oxide, modulating synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2983 54195 Ensembl ENSG00000061918 ENSMUSG00000028005 UniProt Q02153 O54865 RefSeq (mRNA) NM_000857 NM_001291951 NM_001291952 NM_001291953 NM_001291954 NM_001291955 NM_001161796 NM_017469 RefSeq (protein) NP_000848 NP_001278880 NP_001278881 NP_001278882 NP_001278883 NP_001278884 NP_001155268 NP_059497 Location (UCSC) Chr 4: 155.76 – 155.81 Mb Chr 3: 81.94 – 81.98 Mb PubMed search [3] [4]
Wikidata
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Function

Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.^[6]

Interactions

GUCY1B3 has been shown to interact with Heat shock protein 90kDa alpha (cytosolic), member A1^[7] and Endothelial NOS.^[7]