Galactitol-1-phosphate 5-dehydrogenase

In enzymology, galactitol-1-phosphate 5-dehydrogenase (EC 1.1.1.251) is an enzyme that catalyzes the chemical reaction

galactitol-1-phosphate

+ NAD⁺

 

 

 

H⁺

 

H⁺

 

L-tagatose 6-phosphate

+ NADH

 

galactitol-1-phosphate 5-dehydrogenase
Identifiers
EC no.	1.1.1.251
CAS no.	167618-25-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The two substrates of this enzyme are galactitol-1-phosphate and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its 3 products are L-tagatose 6-phosphate (shown in its open-chain keto form), reduced NADH, and a proton.^[1][2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is galactitol-1-phosphate:NAD⁺ oxidoreductase. This enzyme participates in galactose metabolism. It employs one cofactor, zinc.