Goblet cell carcinoid

The goblet cell carcinoid (GCC) is a rare biphasic gastrointestinal tract tumour that consists of a neuroendocrine component and a conventional carcinoma, histologically arising from Paneth cells.^[1]

Goblet cell carcinoid
Other names	Crypt cell carcinoma, neuroendocrine tumour with goblet cell differentiation
Micrograph showing a goblet cell carcinoid. H&E stain.

Sign and symptoms

GCCs may present as appendicitis.

Diagnosis

Micrograph of a goblet cell carcinoid. H&E stain.

GCCs are diagnosed by pathology. They have a characteristic biphasic appearance which includes (1) goblet cell-like cells, and (2) neuroendocrine-type nuclear chromatin (stippled chromatin).

Prognosis

GCCs have an aggressive course compared to other appendiceal neuroendocrine tumours.^[1]

Treatment

GCCs are treated with surgery.

See also

• Neuroendocrine tumours