Group II pyridoxal-dependent decarboxylases

In molecular biology, group II pyridoxal-dependent decarboxylases are a family of enzymes including aromatic-L-amino-acid decarboxylase (L-dopa decarboxylase or tryptophan decarboxylase) EC 4.1.1.28 that catalyse the decarboxylation of tryptophan to tryptamine, tyrosine decarboxylase EC 4.1.1.25 that converts tyrosine into tyramine and histidine decarboxylase EC 4.1.1.22 that catalyses the decarboxylation of histidine to histamine.^[1][2]

Pyridoxal-dependent decarboxylase conserved domain
crystal structure of the murine class ii allele i-a(g7) complexed with the glutamic acid decarboxylase (gad65) peptide 207-220
Identifiers
Symbol	Pyridoxal_deC
Pfam	PF00282
Pfam clan	CL0061
InterPro	IPR002129
PROSITE	PDOC00329
SCOP2	1js3 / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Pyridoxal-5'-phosphate-dependent amino acid decarboxylases can be divided into four groups based on amino acid sequence: group II includes glutamate, histidine, tyrosine, and aromatic-L-amino-acid decarboxylases.^[3]

See also

• Group I pyridoxal-dependent decarboxylases
• Group III pyridoxal-dependent decarboxylases
• Group IV pyridoxal-dependent decarboxylases