Group I pyridoxal-dependent decarboxylases

In molecular biology, the group I pyridoxal-dependent decarboxylases, also known as glycine cleavage system P-proteins, are a family of enzymes consisting of glycine cleavage system P-proteins (glycine dehydrogenase (decarboxylating)) EC 1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex (GDC) also annotated as glycine cleavage system or glycine synthase. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor, carbon dioxide is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. GDC consists of four proteins P, H, L and T.^[1]

Glycine cleavage system P-protein
crystal structure of glycine decarboxylase (p-protein) of the glycine cleavage system, in apo form
Identifiers
Symbol	GDC-P
Pfam	PF02347
Pfam clan	CL0061
InterPro	IPR020580
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Pyridoxal-5'-phosphate-dependent amino acid decarboxylases can be divided into four groups based on amino acid sequence. Group I comprises glycine decarboxylases.^[2]

See also

• Group II pyridoxal-dependent decarboxylases
• Group III pyridoxal-dependent decarboxylases
• Group IV pyridoxal-dependent decarboxylases