H6PD

GDH/6PGL endoplasmic bifunctional protein is a protein that in humans is encoded by the H6PD gene.^[5][6]

H6PD
Identifiers
Aliases	H6PD, CORTRD1, G6PDH, GDH, hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase, H6PDH
External IDs	OMIM: 138090; MGI: 2140356; HomoloGene: 48275; GeneCards: H6PD; OMA:H6PD - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.22 Start 9,234,774 bp[1] End 9,271,337 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 E2|4 80.65 cM Start 150,063,932 bp[2] End 150,093,480 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland germinal epithelium nipple right lobe of liver stromal cell of endometrium body of tongue synovial joint pericardium thoracic diaphragm cardia Top expressed in left lobe of liver lactiferous gland submandibular gland endothelial cell of lymphatic vessel white adipose tissue epithelium of small intestine Ileal epithelium left lung brown adipose tissue right lung More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glucose-6-phosphate dehydrogenase activity oxidoreductase activity 6-phosphogluconolactonase activity glucose 1-dehydrogenase [NAD(P) activity] catalytic activity hydrolase activity NADP binding oxidoreductase activity, acting on CH-OH group of donors Cellular component endoplasmic reticulum lumen endoplasmic reticulum Biological process pentose-phosphate shunt metabolism glucose metabolic process carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9563 100198 Ensembl ENSG00000049239 ENSMUSG00000028980 UniProt O95479 Q8CFX1 RefSeq (mRNA) NM_001282587 NM_004285 NM_001291004 NM_173371 RefSeq (protein) NP_001269516 NP_004276 NP_001277933 NP_775547 Location (UCSC) Chr 1: 9.23 – 9.27 Mb Chr 4: 150.06 – 150.09 Mb PubMed search [3] [4]
Wikidata
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Function

There are two forms of glucose-6-phosphate dehydrogenase. G form is X-linked and H form, encoded by this gene, is autosomally linked. This H form shows activity with other hexose-6-phosphates, especially galactose-6-phosphate, whereas the G form is specific for glucose-6-phosphate. Both forms are present in most tissues, but H form is not found in red cells.^[6]