HABP2

Hyaluronan-binding protein 2 also known as factor VII activating protease (FSAP) is a protein that in humans is encoded by the HABP2 gene.^[5][6][7]

HABP2
Identifiers
Aliases	HABP2, FSAP, HABP, HGFAL, PHBP, NMTC5, hyaluronan binding protein 2
External IDs	OMIM: 603924; MGI: 1196378; HomoloGene: 3050; GeneCards: HABP2; OMA:HABP2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q25.3 Start 113,550,837 bp[1] End 113,589,602 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 D2 Start 56,275,569 bp[2] End 56,309,254 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver pancreatic ductal cell gallbladder oocyte secondary oocyte body of pancreas islet of Langerhans human kidney gonad muscle of thigh Top expressed in right kidney yolk sac crypt of lieberkuhn of small intestine liver human kidney left lobe of liver proximal tubule stomach epithelium of stomach muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity glycosaminoglycan binding serine-type peptidase activity hydrolase activity calcium ion binding serine-type endopeptidase activity Cellular component extracellular region extracellular space Biological process cell adhesion proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3026 226243 Ensembl ENSG00000148702 ENSMUSG00000025075 UniProt Q14520 Q8K0D2 RefSeq (mRNA) NM_004132 NM_001177660 NM_146101 NM_001329935 NM_001329936 RefSeq (protein) NP_001171131 NP_004123 NP_001316864 NP_001316865 NP_666213 Location (UCSC) Chr 10: 113.55 – 113.59 Mb Chr 19: 56.28 – 56.31 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is an extracellular serine protease which binds hyaluronic acid. It is involved in cell adhesion. The protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. Two transcript variants utilizing alternative polyA sites exist for this gene.^[7]