HACE1

HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 is a protein that in humans is encoded by the HACE1 gene.^[4]

HACE1
Identifiers
Aliases	HACE1, SPPRS, HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
External IDs	OMIM: 610876; MGI: 2446110; HomoloGene: 10807; GeneCards: HACE1; OMA:HACE1 - orthologs
Gene location (Mouse) Chr. Chromosome 10 (mouse)[1] Band 10|10 B2 Start 45,453,925 bp[1] End 45,588,441 bp[1]
Gene ontology Molecular function protein binding ubiquitin-protein transferase activity transferase activity ubiquitin protein ligase activity Cellular component cytoplasm Golgi cisterna membrane Golgi membrane Golgi apparatus membrane endoplasmic reticulum nucleus nuclear body Biological process protein K48-linked ubiquitination cell cycle Rac protein signal transduction regulation of cell migration regulation of transcription, DNA-templated membrane fusion Golgi organization protein ubiquitination transcription, DNA-templated ubiquitin-dependent protein catabolic process protein polyubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57531 209462 Ensembl ENSG00000085382 ENSMUSG00000038822 UniProt Q8IYU2 Q3U0D9 RefSeq (mRNA) NM_020771 NM_001321080 NM_001321083 NM_001321084 NM_172473 RefSeq (protein) NP_001308009 NP_001308012 NP_001308013 NP_065822 NP_001337483 NP_001337484 NP_001337485 NP_001337486 NP_001337487 NP_001337488 NP_001337489 NP_766061 Location (UCSC) n/a Chr 10: 45.45 – 45.59 Mb PubMed search [2] [3]
Wikidata
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Function

This gene encodes a HECT domain and ankyrin repeat-containing ubiquitin ligase. The encoded protein is involved in specific tagging of target proteins, leading to their subcellular localization or proteasomal degradation. The protein is a potential tumor suppressor and is involved in the pathophysiology of several tumors, including Wilm's tumor. [provided by RefSeq, Mar 2016].