HAT1

Histone acetyltransferase 1, also known as HAT1, is an enzyme that, in humans, is encoded by the HAT1 gene.^[5][6]

HAT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2P0W
Identifiers
Aliases	HAT1, KAT1, histone acetyltransferase 1
External IDs	OMIM: 603053; MGI: 96013; HomoloGene: 2701; GeneCards: HAT1; OMA:HAT1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q31.1 Start 171,922,448 bp[1] End 171,983,686 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C2 Start 71,219,302 bp[2] End 71,271,966 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ventricular zone biceps brachii Skeletal muscle tissue of rectus abdominis palpebral conjunctiva amniotic fluid Skeletal muscle tissue of biceps brachii mucosa of paranasal sinus bronchial epithelial cell cartilage tissue Top expressed in spermatid Gonadal ridge epiblast primitive streak tail of embryo embryo maxillary prominence mandibular prominence medial ganglionic eminence somite More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity histone binding H4 histone acetyltransferase activity histone acetyltransferase activity protein binding acyltransferase activity Cellular component cytoplasm intracellular membrane-bounded organelle nuclear matrix nucleoplasm nucleus protein-containing complex Biological process response to nutrient internal protein amino acid acetylation DNA replication-dependent chromatin assembly histone acetylation histone H4 acetylation chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8520 107435 Ensembl ENSG00000128708 ENSMUSG00000027018 UniProt O14929 Q8BY71 RefSeq (mRNA) NM_001033085 NM_003642 NM_026115 RefSeq (protein) NP_003633 NP_080391 Location (UCSC) Chr 2: 171.92 – 171.98 Mb Chr 2: 71.22 – 71.27 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are, in turn, imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, in particular, of histone H4, plays an important role in replication-dependent chromatin assembly. To be specific, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and, to a lesser degree, histone H2A at lysine 5.^[6]