HDHD1A

Haloacid dehalogenase-like hydrolase domain-containing protein 1A is an enzyme that in humans is encoded by the HDHD1A gene.^[5][6][7] It encodes a pseudouridine-5'-phosphatase but can also accommodate other phopshorylated metabolites with a lower affinity.^[8][9]

PUDP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3L5K
Identifiers
Aliases	PUDP, DXF68S1E, FAM16AX, GS1, HDHD1A, HDHD1, pseudouridine 5'-phosphatase
External IDs	OMIM: 306480; MGI: 1914615; HomoloGene: 8093; GeneCards: PUDP; OMA:PUDP - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.31 Start 6,667,865 bp[1] End 7,148,158 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 D1 Start 50,696,948 bp[2] End 50,734,491 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis gonad mucosa of sigmoid colon biceps brachii secondary oocyte deltoid muscle Skeletal muscle tissue of biceps brachii tibialis anterior muscle epithelium of bronchus bronchial epithelial cell Top expressed in seminiferous tubule spermatid spermatocyte zygote secondary oocyte primary oocyte islet of Langerhans More reference expression data BioGPS More reference expression data
Gene ontology Molecular function pseudouridine 5'-phosphatase activity hydrolase activity metal ion binding phosphatase activity molecular function magnesium ion binding Cellular component cytosol cytoplasm Biological process pyrimidine nucleoside salvage metabolism nucleotide metabolic process dephosphorylation biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8226 67365 Ensembl ENSG00000130021 ENSMUSG00000048875 UniProt Q08623 Q9D5U5 RefSeq (mRNA) NM_012080 NM_001135565 NM_001178135 NM_001178136 NM_026108 RefSeq (protein) NP_001129037 NP_001171606 NP_001171607 NP_036212 NP_080384 Location (UCSC) Chr X: 6.67 – 7.15 Mb Chr 18: 50.7 – 50.73 Mb PubMed search [3] [4]
Wikidata
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