HEBP1

Heme binding protein 1 is a protein that in humans is encoded by the HEBP1 gene.^[5]

HEBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GOV, 2HVA, 4A1M
Identifiers
Aliases	HEBP1, HBP, HEBP, heme binding protein 1
External IDs	OMIM: 605826; MGI: 1333880; HomoloGene: 8407; GeneCards: HEBP1; OMA:HEBP1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.1 Start 12,974,870 bp[1] End 13,000,265 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 G1 Start 135,114,520 bp[2] End 135,175,020 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa duodenum mucosa of ileum right adrenal gland right adrenal cortex left adrenal gland trabecular bone parotid gland left adrenal cortex left lobe of thyroid gland Top expressed in fetal liver hematopoietic progenitor cell left lobe of liver yolk sac tibiofemoral joint spleen white adipose tissue subcutaneous adipose tissue gastrula migratory enteric neural crest cell efferent ductule More reference expression data BioGPS n/a
Gene ontology Molecular function heme binding Cellular component cytoplasm extracellular region extracellular exosome cytosol Biological process circadian rhythm G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50865 15199 Ensembl ENSG00000013583 ENSMUSG00000042770 UniProt Q9NRV9 Q9R257 RefSeq (mRNA) NM_015987 NM_013546 RefSeq (protein) NP_057071 NP_038574 Location (UCSC) Chr 12: 12.97 – 13 Mb Chr 6: 135.11 – 135.18 Mb PubMed search [3] [4]
Wikidata
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Function

The full-length protein encoded by this gene is an intracellular tetrapyrrole-binding protein. This protein includes a natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide receptor-like receptor 2 (FPRL2) and promotes calcium mobilization and chemotaxis in monocytes and dendritic cells.^[5]