HECW1

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 is a protein that in humans is encoded by the HECW1 gene.^[5] In human it has 1606 amino acids (179.5 kDa) and isoelectric point of 5.18.^[6]

HECW1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3L4H
Identifiers
Aliases	HECW1, NEDL1, HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
External IDs	OMIM: 610384; MGI: 2444115; HomoloGene: 9004; GeneCards: HECW1; OMA:HECW1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p14.1-p13 Start 43,112,629 bp[1] End 43,566,001 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 A1|13 5.29 cM Start 14,401,023 bp[2] End 14,697,813 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 middle temporal gyrus endothelial cell primary visual cortex testicle ganglionic eminence prefrontal cortex dorsolateral prefrontal cortex superior frontal gyrus pons Top expressed in medial dorsal nucleus facial motor nucleus primary motor cortex anterior horn of spinal cord central gray substance of midbrain medial geniculate nucleus medial vestibular nucleus prefrontal cortex trigeminal ganglion lateral geniculate nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity ubiquitin-protein transferase activity ubiquitin protein ligase activity Cellular component cytosol cytoplasm Biological process negative regulation of canonical Wnt signaling pathway protein ubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process protein polyubiquitination ubiquitin-dependent protein catabolic process positive regulation of protein catabolic process regulation of dendrite morphogenesis negative regulation of sodium ion transmembrane transporter activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23072 94253 Ensembl ENSG00000002746 ENSMUSG00000021301 UniProt Q76N89 Q8K4P8 RefSeq (mRNA) NM_001287059 NM_015052 NM_001081348 NM_153130 NM_178809 RefSeq (protein) NP_001273988 NP_055867 NP_001074817 Location (UCSC) Chr 7: 43.11 – 43.57 Mb Chr 13: 14.4 – 14.7 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse