HEPN1

Hepatocellular carcinoma, down-regulated 1 is a protein that in humans is encoded by the HEPN1 gene. ^[3]

HEPN1
Identifiers
Aliases	HEPN1, hepatocellular carcinoma, down-regulated 1
External IDs	OMIM: 611641; HomoloGene: 134601; GeneCards: HEPN1; OMA:HEPN1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q24.2 Start 124,919,244 bp[1] End 124,920,677 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle amygdala putamen C1 segment substantia nigra caudate nucleus hippocampus proper nucleus accumbens right frontal lobe hypothalamus n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 641654 n/a Ensembl ENSG00000221932 n/a UniProt Q6WQI6 n/a RefSeq (mRNA) NM_001037558 n/a RefSeq (protein) NP_001032647 n/a Location (UCSC) Chr 11: 124.92 – 124.92 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

This gene is expressed in the liver, and encodes a short peptide that is localized predominantly to the cytoplasm. Transient transfection studies showed that expression of this gene significantly inhibited cell growth, and it may have a role in apoptosis. Expression of this gene is downregulated or lost in hepatocellular carcinomas (HCC), suggesting that loss of this gene is involved in carcinogenesis of hepatocytes.^[4] Also to note is that this gene maps to the 3'-noncoding region of the HEPACAM gene (GeneID:220296) on the antisense strand.^[5]