HEPPS (buffer)

HEPPS (EPPS) is a buffering agent used in biology and biochemistry. The pKa of HEPPS is 8.00. It is ones of Good's buffers.^[1]

HEPPS

HEPPS
Names
Preferred IUPAC name 3-[4-(2-Hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid
Other names HEPPS, EPPS
Identifiers
CAS Number	16052-06-5
3D model (JSmol)	Interactive image
ChEBI	CHEBI:42298 Y
ChemSpider	76886 Y
ECHA InfoCard	100.036.528
PubChem CID	85255
UNII	8JN5PQW99C Y
CompTox Dashboard (EPA)	DTXSID3066003
InChI InChI=1S/C9H20N2O4S/c12-8-7-11-5-3-10(4-6-11)2-1-9-16(13,14)15/h12H,1-9H2,(H,13,14,15) Y Key: OWXMKDGYPWMGEB-UHFFFAOYSA-N Y InChI=1/C9H20N2O4S/c12-8-7-11-5-3-10(4-6-11)2-1-9-16(13,14)15/h12H,1-9H2,(H,13,14,15) Key: OWXMKDGYPWMGEB-UHFFFAOYAP
SMILES O=S(=O)(O)CCCN1CCN(CCO)CC1
Properties
Chemical formula	C9H20N2O4S
Molar mass	252.33 g·mol−1
Melting point	(decomposes)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Y verify (what is YN ?) Infobox references

Research on mice with Alzheimer's disease-like amyloid beta plaques has shown that HEPPS can cause the plaques to break up, reversing some of the symptoms in the mice.^[2][3][4] HEPPS was reported to dissociate amyloid beta oligomers in patients' plasma samples enabling blood diagnosis of Alzheimer's disease.^[5][6][7]

See also

• CAPSO
• CHES
• HEPES