HERC3

Probable E3 ubiquitin-protein ligase HERC3 is an enzyme that in humans is encoded by the HERC3 gene.^[1][2] The gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and an RCC1-like domain (RLD). It binds ubiquitin and hPLIC-1/2 via its HECT domain. Alternatively spliced transcript variants encoding multiple isoforms have been observed, and mutations in this gene have been linked to colorectal and gastric carcinomas. The protein is localized in the cytosol and vesicular-like structures containing β-COP, ARF, and Rab5. Since HERC3 can itself be ubiquitinated and degraded by the proteasome, it likely has roles in both vesicular traffic and ubiquitin-dependent processes.^[3][4][5]

HERC3
Identifiers
Symbol	HERC3
Alt. names	HECT domain and RCC1-like domain-containing protein 3, HECT-type E3 ubiquitin transferase HERC3, KIAA0032
NCBI gene	8916
HGNC	4876
OMIM	605200
PDB	Q15034
RefSeq	NM_001271602, NM_001318505 NM_014606, NM_001271602, NM_001318505
UniProt	Q15034
Other data
EC number	2.3.2.26
Locus	Chr. 4 q22.1:88,592,422-88,709,302
Search for Structures Swiss-model Domains InterPro