RCC1

Regulator of chromosome condensation 1, also known as RCC1, Ran guanine nucleotide exchange factor and RanGEF, is the name for a human gene and protein.^[5]

RCC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A12, 1I2M, 5E1O, 5E2A, 5E1M, 5E2B, 5E1D, 5E1B
Identifiers
Aliases	RCC1, CHC1, RCC1-I, SNHG3-regulator of chromosome condensation 1
External IDs	OMIM: 179710; MGI: 1913989; HomoloGene: 55567; GeneCards: RCC1; OMA:RCC1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.3 Start 28,505,943 bp[1] End 28,539,300 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.3 Start 132,059,230 bp[2] End 132,080,916 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis ventricular zone sperm islet of Langerhans ganglionic eminence mucosa of transverse colon stromal cell of endometrium oocyte rectum Top expressed in epiblast spermatocyte embryo embryo ventricular zone yolk sac spermatid somite primitive streak fetal liver hematopoietic progenitor cell More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding guanyl-nucleotide exchange factor activity histone binding chromatin binding protein binding nucleosomal DNA binding nucleosome binding sulfate binding protein heterodimerization activity Cellular component cytoplasm nuclear membrane nucleoplasm condensed nuclear chromosome nucleus chromatin chromosome protein-containing complex Biological process chromosome segregation G1 phase mitotic spindle organization cell division spindle assembly cell cycle viral process regulation of mitotic nuclear division protein heterotetramerization regulation of molecular function G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1104 100088 Ensembl ENSG00000180198 ENSMUSG00000028896 UniProt P18754 Q5T081 Q8VE37 RefSeq (mRNA) NM_001048194 NM_001048195 NM_001048199 NM_001269 NM_001381865 NM_001381866 NM_001197082 NM_133878 RefSeq (protein) NP_001041659 NP_001041660 NP_001041664 NP_001260 NP_001368794 NP_001368795 NP_001041664.1 NP_001260.1 NP_001184011 NP_598639 Location (UCSC) Chr 1: 28.51 – 28.54 Mb Chr 4: 132.06 – 132.08 Mb PubMed search [3] [4]
Wikidata
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RCC1 also functions as a guanine nucleotide exchange factor for Ran GTPase.

Interactions

RCC1 has been shown to interact with RANBP3^[6][7] and Ran (biology).^{[8][9][10][11]}