HERC5

E3 ISG15–protein ligase HERC5 is an enzyme that in humans is encoded by the HERC5 gene.^[3][4]

HERC5
Identifiers
Aliases	HERC5, CEB1, CEBP1, HECT and RLD domain containing E3 ubiquitin protein ligase 5
External IDs	OMIM: 608242; HomoloGene: 81848; GeneCards: HERC5; OMA:HERC5 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q22.1 Start 88,457,119 bp[1] End 88,506,163 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle right testis sperm left testis germinal epithelium monocyte palpebral conjunctiva body of uterus left ovary n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ISG15 transferase activity protein binding transferase activity RNA binding ubiquitin-protein transferase activity ubiquitin protein ligase activity Cellular component perinuclear region of cytoplasm cytosol cytoplasm Biological process ISG15-protein conjugation negative regulation of type I interferon production regulation of cyclin-dependent protein serine/threonine kinase activity regulation of defense response to virus defense response to virus immune system process protein polyubiquitination innate immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51191 n/a Ensembl ENSG00000138646 n/a UniProt Q9UII4 n/a RefSeq (mRNA) NM_016323 n/a RefSeq (protein) NP_057407 n/a Location (UCSC) Chr 4: 88.46 – 88.51 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4.^[4] HERC5 has been shown to exhibit antiviral activity towards HIV-1, influenza A virus and human papillomavirus.^[5][6][7]

Interactions

HERC5 has been shown to interact with NME2^[8] and Cyclin E1.^[3]