HERPUD1

Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein is a protein that in humans is encoded by the HERPUD1 gene.^[5][6][7]

HERPUD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WGD
Identifiers
Aliases	HERPUD1, HERP, Mif1, SUP, homocysteine inducible ER protein with ubiquitin like domain 1
External IDs	OMIM: 608070; MGI: 1927406; HomoloGene: 40973; GeneCards: HERPUD1; OMA:HERPUD1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q13 Start 56,932,142 bp[1] End 56,944,864 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C5 Start 95,113,066 bp[2] End 95,122,005 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas palpebral conjunctiva epithelium of nasopharynx tonsil trachea tibia parietal pleura rectum olfactory bulb pylorus Top expressed in lacrimal gland parotid gland right kidney seminal vesicula submandibular gland left lobe of liver islet of Langerhans pyloric antrum calvaria gallbladder More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane transporter binding protein binding molecular function ubiquitin ligase-substrate adaptor activity Cellular component integral component of membrane Lewy body core calcium channel complex endoplasmic reticulum membrane membrane endoplasmic reticulum Biological process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ubiquitin-dependent protein catabolic process negative regulation of intrinsic apoptotic signaling pathway regulation of protein ubiquitination regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway cellular calcium ion homeostasis endoplasmic reticulum calcium ion homeostasis response to endoplasmic reticulum stress PERK-mediated unfolded protein response positive regulation of ER-associated ubiquitin-dependent protein catabolic process regulation of ER-associated ubiquitin-dependent protein catabolic process response to unfolded protein retrograde protein transport, ER to cytosol positive regulation of protein binding endoplasmic reticulum unfolded protein response protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9709 64209 Ensembl ENSG00000051108 ENSMUSG00000031770 UniProt Q15011 Q9JJK5 RefSeq (mRNA) NM_001010989 NM_001010990 NM_001272103 NM_014685 NM_022331 NM_001357205 RefSeq (protein) NP_001010989 NP_001259032 NP_055500 NP_001259032.1 NP_071726 NP_001344134 Location (UCSC) Chr 16: 56.93 – 56.94 Mb Chr 8: 95.11 – 95.12 Mb PubMed search [3] [4]
Wikidata
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The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined.^[7]

Interactions

HERPUD1 has been shown to interact with UBQLN1^[8] and UBQLN2.^[8]