HES5

Transcription factor HES-5 is a protein that in humans is encoded by the HES5 gene.^[5][6]

HES5
Identifiers
Aliases	HES5, bHLHb38, hes family bHLH transcription factor 5
External IDs	OMIM: 607348; MGI: 104876; HomoloGene: 7755; GeneCards: HES5; OMA:HES5 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.32 Start 2,528,745 bp[1] End 2,530,263 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 E2|4 86.01 cM Start 155,045,380 bp[2] End 155,046,828 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ventricular zone ganglionic eminence nucleus accumbens amygdala hypothalamus apex of heart anterior cingulate cortex caudate nucleus putamen Top expressed in medial ganglionic eminence Rostral migratory stream ventricular zone somite neural tube substantia nigra thin ascending limb of loop of Henle supraoptic nucleus olfactory bulb lateral septal nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein dimerization activity transcription factor binding chromatin binding DNA-binding transcription repressor activity, RNA polymerase II-specific double-stranded DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription corepressor activity sequence-specific DNA binding sequence-specific double-stranded DNA binding Cellular component nucleoplasm nucleus cellular component Biological process Notch signaling pathway auditory receptor cell fate determination establishment of epithelial cell polarity cell differentiation negative regulation of astrocyte differentiation regulation of inner ear auditory receptor cell differentiation regulation of transcription, DNA-templated negative regulation of neuron differentiation inner ear receptor cell stereocilium organization comma-shaped body morphogenesis metanephric nephron tubule morphogenesis chondrocyte differentiation central nervous system myelination negative regulation of transcription by RNA polymerase II cell maturation negative regulation of forebrain neuron differentiation transcription, DNA-templated nervous system development negative regulation of stem cell differentiation neuronal stem cell population maintenance positive regulation of transcription, DNA-templated multicellular organism development glial cell fate commitment telencephalon development brain development inner ear auditory receptor cell differentiation cell adhesion astrocyte differentiation cartilage development forebrain radial glial cell differentiation regulation of myelination negative regulation of oligodendrocyte differentiation S-shaped body morphogenesis neural tube development neuron differentiation positive regulation of cell population proliferation positive regulation of BMP signaling pathway negative regulation of pro-B cell differentiation regulation of cell differentiation smoothened signaling pathway oligodendrocyte development camera-type eye development specification of loop of Henle identity regulation of epithelial cell proliferation negative regulation of transcription, DNA-templated negative regulation of inner ear receptor cell differentiation regulation of neurogenesis positive regulation of receptor signaling pathway via JAK-STAT positive regulation of Notch signaling pathway positive regulation of transcription by RNA polymerase II positive regulation of smooth muscle cell proliferation positive regulation of tyrosine phosphorylation of STAT protein protein-containing complex assembly somitogenesis central nervous system development anterior/posterior pattern specification negative regulation of inner ear auditory receptor cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 388585 15208 Ensembl ENSG00000273529 ENSG00000197921 ENSMUSG00000048001 UniProt Q5TA89 P70120 RefSeq (mRNA) NM_001010926 NM_010419 NM_001370755 RefSeq (protein) NP_001010926 NP_034549 NP_001357684 Location (UCSC) Chr 1: 2.53 – 2.53 Mb Chr 4: 155.05 – 155.05 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

HES5 regulates the development of the early brain by maintaining stem cell neural progenitors in the ventricular zone.^[7][8] HES5 expression significantly higher in squamous cervical carcinoma than in CIN as well as higher in CIN than normal cervical epithelia.^[9] Human HES5 gene binds to Notch receptor and expression of HES5 decreases during cartilage differentiation.^[10]