HFM1

HFM1 is a gene that in humans encodes a protein necessary for homologous recombination of chromosomes.^[5] Biallelic mutations in HFM1 cause recessive primary ovarian insufficiency.^[5]

HFM1
Identifiers
Aliases	HFM1, MER3, POF9, SEC63D1, Si-11, Si-11-6, helicase, ATP-dependent DNA helicase homolog, ATP dependent DNA helicase homolog, helicase for meiosis 1
External IDs	OMIM: 615684; MGI: 3036246; HomoloGene: 87103; GeneCards: HFM1; OMA:HFM1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p22.2 Start 91,260,766 bp[1] End 91,404,856 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E5 Start 106,840,192 bp[2] End 106,926,321 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad pituitary gland anterior pituitary right testis left testis ventricular zone cerebellar hemisphere right hemisphere of cerebellum ganglionic eminence Top expressed in spermatocyte spermatid testicle ganglionic eminence Mesencephalon ventricular zone embryo embryo neural tube secondary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function ATP binding hydrolase activity nucleotide binding nucleic acid binding helicase activity Cellular component nucleolus cytoplasm Biological process resolution of meiotic recombination intermediates meiosis RNA secondary structure unwinding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 164045 330149 Ensembl ENSG00000162669 ENSMUSG00000043410 UniProt A2PYH4 C9JQ07 D3Z4R1 RefSeq (mRNA) NM_001017975 NM_001252516 NM_177873 RefSeq (protein) NP_001017975 NP_001239445 NP_808541 Location (UCSC) Chr 1: 91.26 – 91.4 Mb Chr 5: 106.84 – 106.93 Mb PubMed search [3] [4]
Wikidata
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