HIC1

Hypermethylated in cancer 1 protein is a protein that in humans is encoded by the HIC1 gene.^[5]

HIC1
Identifiers
Aliases	HIC1, ZBTB29, ZNF901, hic-1, hypermethylated in cancer 1, HIC ZBTB transcriptional repressor 1
External IDs	OMIM: 603825; MGI: 1338010; HomoloGene: 4740; GeneCards: HIC1; OMA:HIC1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.3 Start 2,054,154 bp[1] End 2,063,241 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B5|11 45.76 cM Start 75,055,391 bp[2] End 75,060,345 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cardiac muscle tissue of right atrium stromal cell of endometrium apex of heart sural nerve vena cava right ovary left ovary left uterine tube body of uterus pericardium Top expressed in internal carotid artery external carotid artery vas deferens efferent ductule Gonadal ridge female urethra dermis placenta gastrula uterus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding histone deacetylase binding protein binding metal ion binding nucleic acid binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component chromatin nucleus cytosol nucleoplasm Biological process multicellular organism development negative regulation of Wnt signaling pathway positive regulation of DNA damage response, signal transduction by p53 class mediator regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II Wnt signaling pathway transcription, DNA-templated intrinsic apoptotic signaling pathway in response to DNA damage cellular response to DNA damage stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3090 15248 Ensembl ENSG00000177374 ENSMUSG00000043099 UniProt Q14526 Q9R1Y5 RefSeq (mRNA) NM_006497 NM_001098202 NM_001098203 NM_010430 RefSeq (protein) NP_001091672 NP_006488 NP_001091673 NP_034560 Location (UCSC) Chr 17: 2.05 – 2.06 Mb Chr 11: 75.06 – 75.06 Mb PubMed search [3] [4]
Wikidata
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