HIC2

Hypermethylated in cancer 2 protein is a protein that in humans is encoded by the HIC2 gene.^[5][6]

HIC2
Identifiers
Aliases	HIC2, HRG22, ZBTB30, ZNF907, hypermethylated in cancer 2, HIC ZBTB transcriptional repressor 2
External IDs	OMIM: 607712; MGI: 1929869; HomoloGene: 9020; GeneCards: HIC2; OMA:HIC2 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.21 Start 21,417,371 bp[1] End 21,451,463 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A3 Start 17,051,436 bp[2] End 17,081,294 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte amniotic fluid endothelial cell placenta gonad vena cava Brodmann area 23 parotid gland Region I of hippocampus proper gingival epithelium Top expressed in zygote secondary oocyte yolk sac female urethra blastocyst abdominal wall mandibular prominence maxillary prominence primitive streak epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein C-terminus binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific Cellular component nucleus Biological process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23119 58180 Ensembl ENSG00000169635 ENSMUSG00000050240 UniProt Q96JB3 Q9JLZ6 RefSeq (mRNA) NM_015094 NM_178922 RefSeq (protein) NP_055909 NP_849253 Location (UCSC) Chr 22: 21.42 – 21.45 Mb Chr 16: 17.05 – 17.08 Mb PubMed search [3] [4]
Wikidata
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