HIF1AN

Hypoxia-inducible factor 1-alpha inhibitor (FIH) is a protein that in humans is encoded by the HIF1AN gene.^[5][6]

HIF1AN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H2K, 1H2L, 1H2M, 1H2N, 1IZ3, 1MZE, 1MZF, 1YCI, 2CGN, 2CGO, 2ILM, 2W0X, 2WA3, 2WA4, 2XUM, 2Y0I, 2YC0, 2YDE, 3D8C, 3KCX, 3KCY, 3OD4, 3P3N, 3P3P, 4AI8, 4B7E, 4B7K, 4BIO, 4JAA, 4NR1, 4Z2W, 4Z1V
Identifiers
Aliases	HIF1AN, FIH1, hypoxia inducible factor 1 alpha subunit inhibitor, hypoxia inducible factor 1 subunit alpha inhibitor, HIFAN
External IDs	OMIM: 606615; MGI: 2442345; HomoloGene: 9906; GeneCards: HIF1AN; OMA:HIF1AN - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.31 Start 100,529,072 bp[1] End 100,559,998 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C3 Start 44,551,289 bp[2] End 44,564,713 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle Skeletal muscle tissue of rectus abdominis muscle of thigh glutes tendon of biceps brachii stromal cell of endometrium triceps brachii muscle quadriceps femoris muscle vastus lateralis muscle islet of Langerhans Top expressed in muscle of thigh knee joint skeletal muscle tissue triceps brachii muscle vastus lateralis muscle sternocleidomastoid muscle tibialis anterior muscle temporal muscle digastric muscle gastrocnemius muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function iron ion binding peptidyl-asparagine 3-dioxygenase activity protein homodimerization activity ankyrin repeat binding zinc ion binding dioxygenase activity metal ion binding NF-kappaB binding Notch binding protein binding carboxylic acid binding oxidoreductase activity peptidyl-histidine dioxygenase activity oxygen gasoreceptor activity 2-oxoglutarate-dependent dioxygenase activity hypoxia-inducible factor-asparagine oxygenase activity Cellular component cytoplasm nucleoplasm perinuclear region of cytoplasm nucleus cytosol Biological process regulation of transcription, DNA-templated peptidyl-histidine hydroxylation transcription, DNA-templated peptidyl-aspartic acid hydroxylation peptidyl-asparagine hydroxylation positive regulation of myoblast differentiation positive regulation of vasculogenesis regulation of transcription from RNA polymerase II promoter in response to hypoxia negative regulation of transcription from RNA polymerase II promoter in response to hypoxia negative regulation of Notch signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55662 319594 Ensembl ENSG00000166135 ENSMUSG00000036450 UniProt Q9NWT6 Q8BLR9 RefSeq (mRNA) NM_017902 NM_176958 RefSeq (protein) NP_060372 NP_795932 Location (UCSC) Chr 10: 100.53 – 100.56 Mb Chr 19: 44.55 – 44.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

FIH has been shown to interact with HIF1A^[5] and Von Hippel-Lindau tumor suppressor.^[5] Additionally, asparaginyl hydroxylation of HIF1α by FIH-1 (HIF1AN) at N803 impairs its interaction with CBP/P300.^[7]