HINT1

Histidine triad nucleotide-binding protein 1 also known as adenosine 5'-monophosphoramidase is an enzyme that in humans is encoded by the HINT1 gene.^[5][6]

HINT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AV5, 1KPA, 1KPB, 1KPC, 1KPE, 1KPF, 3TW2, 4EQE, 4EQG, 4EQH, 4ZKL, 4ZKV, 5I2E, 5I2F
Identifiers
Aliases	HINT1, HINT, NMAN, PKCI-1, PRKCNH1, histidine triad nucleotide binding protein 1
External IDs	OMIM: 601314; MGI: 1321133; HomoloGene: 3904; GeneCards: HINT1; OMA:HINT1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q23.3 Start 131,155,383 bp[1] End 131,224,468 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 54,757,209 bp[2] End 54,761,327 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell oocyte middle temporal gyrus Brodmann area 23 Pons epithelium of nasopharynx gingival epithelium renal medulla seminal vesicula spinal ganglia Top expressed in fossa renal corpuscle Paneth cell condyle endothelial cell of lymphatic vessel medullary collecting duct facial motor nucleus barrel cortex Epithelium of choroid plexus vas deferens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding catalytic activity hydrolase activity protein kinase C binding Cellular component histone deacetylase complex plasma membrane extracellular exosome cytoskeleton nucleus cytoplasm cytosol Biological process purine ribonucleotide catabolic process positive regulation of calcium-mediated signaling regulation of transcription, DNA-templated transcription, DNA-templated intrinsic apoptotic signaling pathway by p53 class mediator signal transduction apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3094 15254 Ensembl ENSG00000169567 ENSMUSG00000020267 UniProt P49773 P70349 RefSeq (mRNA) NM_005340 NM_008248 RefSeq (protein) NP_005331 NP_032274 Location (UCSC) Chr 5: 131.16 – 131.22 Mb Chr 11: 54.76 – 54.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

HINT1 hydrolyzes purine nucleotide phosphoramidates with a single phosphate group.^[7] In addition, functions as scaffolding protein that modulates transcriptional activation.^[8]

It is a haploinsufficient tumor suppressor gene that inhibits the Wnt/β-catenin pathway in colon cancer cells and microphthalmia-associated transcription factor (MITF) activity in human mast cells.^[9][10] In the LysRS-Ap4A-MITF signaling pathway, HINT1 inhibits the MITF transcriptional activity by direct association. Upon pathway activation, HINT1 is released from MITF by diadenosine tetraphosphate (Ap4A), produced by LysRS.^[10][11]

See also

• Histidine triad nucleotide-binding protein 2 (HINT2)