HIRIP3

HIRA-interacting protein 3 is a protein that in humans is encoded by the HIRIP3 gene.^[5][6]

HIRIP3
Identifiers
Aliases	HIRIP3, HIRA interacting protein 3
External IDs	OMIM: 603365; MGI: 2142364; HomoloGene: 18218; GeneCards: HIRIP3; OMA:HIRIP3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 29,992,330 bp[1] End 29,996,074 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 126,461,144 bp[2] End 126,464,549 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte left testis right testis ganglionic eminence ventricular zone apex of heart C1 segment secondary oocyte gastrocnemius muscle muscle of thigh Top expressed in zygote otic vesicle neural layer of retina secondary oocyte tail of embryo hand ventricular zone primary oocyte genital tubercle epiblast More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 8479 233876 Ensembl ENSG00000149929 ENSMUSG00000042606 UniProt Q9BW71 Q8BLH7 RefSeq (mRNA) NM_003609 NM_001197323 NM_172746 RefSeq (protein) NP_001184252 NP_003600 NP_766334 Location (UCSC) Chr 16: 29.99 – 30 Mb Chr 7: 126.46 – 126.46 Mb PubMed search [3] [4]
Wikidata
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The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a protein complex. Recently, several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the HIRIP3 gene product binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism.^[6]