HIVEP3

Transcription factor HIVEP3 is a protein that in humans is encoded by the HIVEP3 gene.^[5][6]

HIVEP3
Identifiers
Aliases	HIVEP3, Hivep3, 2900056N03Rik, A130075N07, AI848000, E030045D18Rik, KBP-1, KBP1, Rc, Schnurri-3, Shn3, Zas3, ZNF40C, human immunodeficiency virus type I enhancer binding protein 3, Kappa Recognition Component (Krc), KRC, HIVEP zinc finger 3
External IDs	OMIM: 606649; MGI: 106589; HomoloGene: 7803; GeneCards: HIVEP3; OMA:HIVEP3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.2 Start 41,506,365 bp[1] End 42,035,925 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.1 Start 119,590,981 bp[2] End 119,995,242 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell endothelial cell Brodmann area 23 cartilage tissue parietal pleura primary visual cortex granulocyte middle temporal gyrus entorhinal cortex germinal epithelium Top expressed in gastrula medial geniculate nucleus Rostral migratory stream subiculum medial dorsal nucleus lateral geniculate nucleus substantia nigra trigeminal ganglion anterior amygdaloid area submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nucleus Biological process multicellular organism development skeletal muscle cell differentiation positive regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription by RNA polymerase II signal transduction transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 59269 16656 Ensembl ENSG00000127124 ENSMUSG00000028634 UniProt Q5T1R4 A2A884 RefSeq (mRNA) NM_001127714 NM_024503 NM_010657 RefSeq (protein) NP_001121186 NP_078779 NP_034787 Location (UCSC) Chr 1: 41.51 – 42.04 Mb Chr 4: 119.59 – 120 Mb PubMed search [3] [4]
Wikidata
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Function

Members of the ZAS family, such as ZAS3 (HIVEP3), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine -rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM]^[6]

It regulates osteoblasts.^[7]

Interactions

HIVEP3 has been shown to interact with TRAF1^[8] and TRAF2.^[8]