HLA-DMA

HLA class II histocompatibility antigen, DM alpha chain is a protein that in humans is encoded by the HLA-DMA gene.^[5][6]

HLA-DMA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HDM, 2BC4, 4FQX, 4GBX
Identifiers
Aliases	HLA-DMA, D6S222E, DMA, HLADM, RING6, major histocompatibility complex, class II, DM alpha
External IDs	OMIM: 142855; MGI: 95921; HomoloGene: 4464; GeneCards: HLA-DMA; OMA:HLA-DMA - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.32 Start 32,948,613 bp[1] End 32,969,094 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 17.98 cM Start 34,338,515 bp[2] End 34,358,075 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte lymph node spleen appendix gallbladder upper lobe of left lung right lung duodenum rectum Top expressed in spleen mesenteric lymph nodes thymus blood lactiferous gland subcutaneous adipose tissue jejunum Paneth cell sciatic nerve ankle joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function MHC class II protein complex binding protein binding Cellular component integral component of membrane cell surface endosome lysosome extracellular exosome late endosome membrane membrane lysosomal membrane MHC class II protein complex intracellular membrane-bounded organelle Biological process antigen processing and presentation of peptide or polysaccharide antigen via MHC class II peptide antigen assembly with MHC class II protein complex antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II immune response immune system process adaptive immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3108 14998 Ensembl ENSG00000243215 ENSG00000243719 ENSG00000239463 ENSG00000204257 ENSG00000242361 ENSG00000241394 ENSG00000243189 ENSG00000242685 ENSMUSG00000037649 UniProt P28067 P28078 Q31621 RefSeq (mRNA) NM_006120 NM_010386 NM_001360530 RefSeq (protein) n/a NP_034516 NP_001347459 Location (UCSC) Chr 6: 32.95 – 32.97 Mb Chr 17: 34.34 – 34.36 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.^[6]