HLA-DQA2

HLA class II histocompatibility antigen, DQ(6) alpha chain is a protein that in humans is encoded by the HLA-DQA2 gene. Also known as HLA-DXA or DAAP-381D23.2, it is part of the human leukocyte antigen system.^[5]

HLA-DQA2
Identifiers
Aliases	HLA-DQA2, DX-ALPHA, HLA-DXA, HLA-DQA2 (gene), major histocompatibility complex, class II, DQ alpha 2, DC-alpha, HLA-DCA, DQA1
External IDs	OMIM: 613503; MGI: 95895; HomoloGene: 134076; GeneCards: HLA-DQA2; OMA:HLA-DQA2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.32 Start 32,741,391 bp[1] End 32,747,198 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 17.98 cM Start 34,501,718 bp[2] End 34,506,797 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte appendix testicle lymph node duodenum spleen right coronary artery upper lobe of left lung right lung mucosa of transverse colon Top expressed in spleen mesenteric lymph nodes Paneth cell thymus submandibular gland right lung right lung lobe tunica adventitia of aorta skin of external ear superior surface of tongue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function MHC class II receptor activity Cellular component integral component of membrane endocytic vesicle membrane clathrin-coated endocytic vesicle membrane endosome Golgi apparatus trans-Golgi network membrane endoplasmic reticulum membrane membrane Golgi membrane plasma membrane transport vesicle membrane integral component of plasma membrane MHC class II protein complex lysosomal membrane endoplasmic reticulum ER to Golgi transport vesicle membrane lysosome integral component of lumenal side of endoplasmic reticulum membrane endosome membrane Biological process antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II interferon-gamma-mediated signaling pathway immune system process antigen processing and presentation of peptide or polysaccharide antigen via MHC class II immune response T cell receptor signaling pathway adaptive immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3118 14960 Ensembl ENSG00000231823 ENSG00000206301 ENSG00000257473 ENSG00000231526 ENSG00000225103 ENSG00000237541 ENSG00000223793 ENSG00000233192 ENSMUSG00000036594 UniProt P01906 P14434 P14437 P01910 P14435 P14438 P04228 P14436 P04227 RefSeq (mRNA) NM_020056 NM_010378 RefSeq (protein) NP_064440 NP_034508 Location (UCSC) Chr 6: 32.74 – 32.75 Mb Chr 17: 34.5 – 34.51 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is expressed, but unlike HLA-DQA1, it is apparently unable to heterodimerize with HLA class II beta chain paralogues.^[6] The low level of HLA-DQA2 expression is apparently due to impaired transcription factor binding to the HLA-DQA2 gene promoter.^[7]

COVID-19

Transcriptome analysis of blood immune cells and nasopharyngeal cells before elaborate infection of study participants revealed that heightened expression of HLA-DQA2 correlates to a significantly lower chance of COVID-19 successfully infecting the individual.^[8]