HMGB2

High-mobility group protein B2 also known as high-mobility group protein 2 (HMG-2) is a protein that in humans is encoded by the HMGB2 gene.^[5][6]

HMGB2
Identifiers
Aliases	HMGB2, HMG2, high mobility group box 2
External IDs	OMIM: 163906; MGI: 96157; HomoloGene: 37582; GeneCards: HMGB2; OMA:HMGB2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q34.1 Start 173,331,376 bp[1] End 173,334,432 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 B2|8 29.9 cM Start 57,964,941 bp[2] End 57,969,033 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone secondary oocyte amniotic fluid embryo trabecular bone ganglionic eminence bone marrow tibia thymus germinal epithelium Top expressed in tail of embryo genital tubercle ventricular zone granulocyte yolk sac zygote embryo blastocyst embryo morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein domain specific binding DNA-binding transcription factor activity transcription factor binding non-sequence-specific DNA binding, bending single-stranded DNA binding damaged DNA binding protein binding four-way junction DNA binding cis-regulatory region sequence-specific DNA binding RAGE receptor binding chemoattractant activity double-stranded DNA binding DNA binding, bending supercoiled DNA binding RNA binding transcription coactivator activity Cellular component cytoplasm nucleoplasm chromosome extracellular region nucleolus perinuclear region of cytoplasm condensed chromosome nucleus extracellular space protein-containing complex Biological process DNA geometric change positive regulation of interferon-beta production nucleosome assembly DNA recombination apoptotic DNA fragmentation male gonad development regulation of transcription, DNA-templated positive regulation of endothelial cell proliferation positive regulation of erythrocyte differentiation inflammatory response to antigenic stimulus immune system process regulation of transcription by RNA polymerase II response to steroid hormone chromatin organization negative regulation of gene expression transcription, DNA-templated positive regulation of transcription, DNA-templated chemotaxis response to lipopolysaccharide positive regulation of gene expression positive regulation of nuclease activity defense response to Gram-negative bacterium negative regulation of extrinsic apoptotic signaling pathway via death domain receptors V(D)J recombination spermatogenesis positive regulation of innate immune response cell chemotaxis DNA ligation involved in DNA repair spermatid nucleus differentiation positive regulation of DNA binding innate immune response negative regulation of transcription, DNA-templated cellular response to lipopolysaccharide inflammatory response positive regulation of megakaryocyte differentiation regulation of neurogenesis regulation of stem cell proliferation DNA topological change positive regulation of transcription by RNA polymerase II defense response to Gram-positive bacterium positive chemotaxis chromatin remodeling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3148 97165 Ensembl ENSG00000164104 ENSMUSG00000054717 UniProt P26583 P30681 RefSeq (mRNA) NM_002129 NM_001130688 NM_001130689 NM_008252 NM_001363443 NM_001363444 NM_001363445 RefSeq (protein) NP_001124160 NP_001124161 NP_002120 NP_032278 NP_001350372 NP_001350373 NP_001350374 Location (UCSC) Chr 4: 173.33 – 173.33 Mb Chr 8: 57.96 – 57.97 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the non-histone chromosomal high-mobility group protein family.^[7] The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.^[6]