HMGB4

High mobility group protein B4 is a transcription factor that in humans is encoded by the HMGB4 gene.^[5]

HMGB4
Identifiers
Aliases	HMGB4, dJ1007G16.5, high mobility group box 4
External IDs	OMIM: 617285; MGI: 1916567; HomoloGene: 83321; GeneCards: HMGB4; OMA:HMGB4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.1 Start 33,860,475 bp[1] End 33,864,791 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 128,154,005 bp[2] End 128,154,750 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis sperm testicle tail of epididymis right coronary artery caput epididymis ectocervix right uterine tube canal of the cervix Top expressed in seminiferous tubule spermatid spermatocyte muscle tissue central gray substance of midbrain striated muscle tissue pancreas skeletal muscle tissue islet of Langerhans hypothalamus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding DNA binding transcription factor binding DNA binding, bending Cellular component nucleus chromosome cytoplasm Biological process activation of innate immune response DNA recombination chromatin remodeling regulation of transcription by RNA polymerase II regulation of signaling receptor activity positive regulation of autophagy developmental process positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of innate immune response positive regulation of transcription by RNA polymerase II cell chemotaxis positive regulation of ERK1 and ERK2 cascade positive regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 127540 69317 Ensembl ENSG00000176256 ENSMUSG00000048686 UniProt Q8WW32 Q6P8W9 RefSeq (mRNA) NM_145205 NM_001352984 NM_001379301 NM_027036 RefSeq (protein) NP_660206 NP_001339913 NP_001366230 NP_081312 Location (UCSC) Chr 1: 33.86 – 33.86 Mb Chr 4: 128.15 – 128.15 Mb PubMed search [3] [4]
Wikidata
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See also

• High-mobility group