HMGN1

Non-histone chromosomal protein HMG-14 is a protein that in humans is encoded by the HMGN1 gene.^[5][6][7]

HMGN1
Identifiers
Aliases	HMGN1, HMG14, high mobility group nucleosome binding domain 1
External IDs	OMIM: 163920; MGI: 96120; HomoloGene: 3643; GeneCards: HMGN1; OMA:HMGN1 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.2 Start 39,342,315 bp[1] End 39,349,647 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 C4|16 56.83 cM Start 95,921,818 bp[2] End 95,928,929 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence endometrium right uterine tube appendix lymph node olfactory zone of nasal mucosa rectum islet of Langerhans bone marrow Top expressed in neural layer of retina yolk sac ventricular zone embryo embryo genital tubercle tail of embryo lip zygote right kidney More reference expression data BioGPS n/a
Gene ontology Molecular function nucleosomal DNA binding DNA binding chromatin binding Cellular component cytoplasm chromatin nucleus nucleoplasm Biological process positive regulation of DNA-templated transcription, elongation pyrimidine dimer repair by nucleotide-excision repair transcription-coupled nucleotide-excision repair chromatin organization regulation of transcription by RNA polymerase II response to UV-B response to UV-C regulation of development, heterochronic post-embryonic camera-type eye morphogenesis regulation of epithelial cell proliferation positive regulation of NAD+ ADP-ribosyltransferase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3150 15312 Ensembl ENSG00000205581 ENSMUSG00000040681 UniProt P05114 P18608 RefSeq (mRNA) NM_004965 NM_008251 RefSeq (protein) NP_004956 NP_032277 Location (UCSC) Chr 21: 39.34 – 39.35 Mb Chr 16: 95.92 – 95.93 Mb PubMed search [3] [4]
Wikidata
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Function

Chromosomal protein HMG14 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation.^[8] Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.^[7]

Interactions

HMGN1 has been shown to interact with YWHAZ.^[9]

See also

• HMGN2
• High mobility group protein HMG14 and HMG17