HNRNPLL

Heterogeneous nuclear ribonucleoprotein L-like is a protein that in humans is encoded by the HNRNPLL gene.^[5]

HNRNPLL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WEX, 2E5I
Identifiers
Aliases	HNRNPLL, HNRPLL, SRRF, heterogeneous nuclear ribonucleoprotein L like
External IDs	OMIM: 611208; MGI: 1919942; HomoloGene: 26701; GeneCards: HNRNPLL; OMA:HNRNPLL - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p22.1 Start 38,561,969 bp[1] End 38,603,586 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E3 Start 80,336,916 bp[2] End 80,369,763 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence pancreatic epithelial cell cartilage tissue parotid gland tail of epididymis left testis right testis saphenous vein gonad Top expressed in medial ganglionic eminence primitive streak abdominal wall somite barrel cortex condyle tail of embryo fossa superior cervical ganglion epiblast More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding mRNA binding nucleic acid binding RNA binding Cellular component membrane nucleus Biological process positive regulation of RNA splicing mRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 92906 72692 Ensembl ENSG00000143889 ENSMUSG00000024095 UniProt Q8WVV9 Q921F4 RefSeq (mRNA) NM_001142650 NM_138394 NM_144802 RefSeq (protein) NP_001136122 NP_612403 NP_659051 Location (UCSC) Chr 2: 38.56 – 38.6 Mb Chr 17: 80.34 – 80.37 Mb PubMed search [3] [4]
Wikidata
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Function

HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation.^[6]