HNRPF

Heterogeneous nuclear ribonucleoprotein F is a protein that in humans is encoded by the HNRNPF gene.^[5][6]

HNRNPF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HGL, 2HGM, 2HGN, 2KFY, 2KG0, 2KG1, 3TFY
Identifiers
Aliases	HNRNPF, HNRPF, OK/SW-cl.23, mcs94-1, heterogeneous nuclear ribonucleoprotein F
External IDs	OMIM: 601037; MGI: 2138741; HomoloGene: 21032; GeneCards: HNRNPF; OMA:HNRNPF - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q11.21 Start 43,385,617 bp[1] End 43,409,186 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 F1 Start 117,877,285 bp[2] End 117,902,583 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence rectum gallbladder olfactory zone of nasal mucosa monocyte islet of Langerhans right uterine tube gonad granulocyte Top expressed in epiblast thymus ventricular zone tail of embryo genital tubercle ovary uterus lung lens intestine More reference expression data BioGPS n/a
Gene ontology Molecular function TBP-class protein binding transcription factor binding protein binding single-stranded RNA binding nucleic acid binding RNA binding Cellular component catalytic step 2 spliceosome spliceosomal complex membrane nucleus nucleoplasm cytosol plasma membrane Biological process mRNA splicing, via spliceosome regulation of RNA splicing mRNA processing RNA processing fibroblast growth factor receptor signaling pathway RNA splicing RNA metabolic process interleukin-12-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3185 98758 Ensembl ENSG00000169813 ENSMUSG00000042079 UniProt P52597 Q9Z2X1 RefSeq (mRNA) NM_004966 NM_001098204 NM_001098205 NM_001098206 NM_001098207 NM_001098208 NM_001166427 NM_001166428 NM_001166429 NM_001166430 NM_001166431 NM_001166432 NM_133834 RefSeq (protein) NP_001091674 NP_001091675 NP_001091676 NP_001091677 NP_001091678 NP_004957 NP_001159899 NP_001159900 NP_001159901 NP_001159902 NP_001159903 NP_001159904 NP_598595 Location (UCSC) Chr 10: 43.39 – 43.41 Mb Chr 6: 117.88 – 117.9 Mb PubMed search [3] [4]
Wikidata
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This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport.

While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs which have guanosine-rich sequences. This protein is very similar to the family member hnRNPH. Multiple alternatively spliced variants, encoding the same protein, have been identified.^[6]