HNRPH2

Heterogeneous nuclear ribonucleoprotein H2 is a protein that in humans is encoded by the HNRNPH2 gene.^[5][6]

HNRNPH2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WEZ, 1WG5
Identifiers
Aliases	HNRNPH2, FTP3, HNRPH', HNRPH2, hnRNPH', heterogeneous nuclear ribonucleoprotein H2 (H'), heterogeneous nuclear ribonucleoprotein H2, MRXSB, NRPH2
External IDs	OMIM: 300610; MGI: 1201779; HomoloGene: 23165; GeneCards: HNRNPH2; OMA:HNRNPH2 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq22.1 Start 101,408,222 bp[1] End 101,414,133 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X E3|X 56.2 cM Start 133,501,928 bp[2] End 133,507,809 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Epithelium of choroid plexus islet of Langerhans seminal vesicula monocyte Skeletal muscle tissue of rectus abdominis palpebral conjunctiva prefrontal cortex ventricular zone human penis endometrium Top expressed in ventricular zone neural layer of retina epiblast dentate gyrus of hippocampal formation granule cell ganglionic eminence neural tube hippocampus proper lens olfactory bulb primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nucleic acid binding RNA binding Cellular component membrane nucleus nucleoplasm cytosol postsynaptic density ribonucleoprotein complex Biological process mRNA splicing, via spliceosome RNA metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3188 56258 Ensembl ENSG00000126945 ENSMUSG00000045427 UniProt P55795 P70333 RefSeq (mRNA) NM_019597 NM_001032393 NM_019868 NM_001313716 NM_001313717 RefSeq (protein) NP_001027565 NP_062543 NP_001300645 NP_001300646 NP_063921 Location (UCSC) Chr X: 101.41 – 101.41 Mb Chr X: 133.5 – 133.51 Mb PubMed search [3] [4]
Wikidata
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This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. This gene is thought to be involved in Fabry disease and X-linked agammaglobulinemia phenotype. Alternative splicing results in multiple transcript variants encoding the same protein.^[6]