HOOK1

Protein Hook homolog 1 is a protein that in humans is encoded by the HOOK1 gene.^[5][6]

HOOK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WIX
Identifiers
Aliases	HOOK1, HK1, hook microtubule-tethering protein 1, hook microtubule tethering protein 1
External IDs	OMIM: 607820; MGI: 1925213; HomoloGene: 9289; GeneCards: HOOK1; OMA:HOOK1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p32.1 Start 59,814,786 bp[1] End 59,876,322 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 C5|4 44.17 cM Start 95,855,477 bp[2] End 95,913,650 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm left testis right testis body of pancreas bronchial epithelial cell islet of Langerhans retinal pigment epithelium jejunal mucosa mucosa of colon gingival epithelium Top expressed in spermatid neural layer of retina lacrimal gland parotid gland retinal pigment epithelium ileum otolith organ utricle left colon spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding protein binding identical protein binding microtubule binding dynein light intermediate chain binding Cellular component HOPS complex cytoplasm microtubule cytoskeleton microtubule cytoskeleton FHF complex cytosol centrosome Biological process multicellular organism development protein transport cell differentiation lysosome organization early endosome to late endosome transport spermatogenesis endosome organization spermatid development endosome to lysosome transport cytoskeleton-dependent intracellular transport cytoplasmic microtubule organization Golgi organization manchette assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51361 77963 Ensembl ENSG00000134709 ENSMUSG00000028572 UniProt Q9UJC3 Q8BIL5 RefSeq (mRNA) NM_015888 NM_030014 RefSeq (protein) NP_056972 NP_084290 Location (UCSC) Chr 1: 59.81 – 59.88 Mb Chr 4: 95.86 – 95.91 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the hook family of coiled coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined.^[6]