HOOK3

Protein Hook homolog 3 is a protein that in humans is encoded by the HOOK3 gene.^[5][6]

HOOK3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5J8E
Identifiers
Aliases	HOOK3, HK3, hook microtubule-tethering protein 3, hook microtubule tethering protein 3
External IDs	OMIM: 607825; MGI: 2443554; HomoloGene: 13022; GeneCards: HOOK3; OMA:HOOK3 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p11.21 Start 42,896,946 bp[1] End 43,030,535 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A2 Start 26,511,449 bp[2] End 26,609,252 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon sural nerve tendon of biceps brachii epithelium of colon pancreatic epithelial cell corpus callosum endothelial cell buccal mucosa cell internal globus pallidus deltoid muscle Top expressed in otolith organ utricle knee joint tibialis anterior muscle hand triceps brachii muscle vastus lateralis muscle Rostral migratory stream tail of embryo foot More reference expression data BioGPS n/a
Gene ontology Molecular function microtubule binding protein binding identical protein binding dynein light intermediate chain binding dynactin binding dynein light chain binding dynein intermediate chain binding Cellular component HOPS complex FHF complex cis-Golgi network centriolar satellite microtubule cytoskeleton cytosol pericentriolar material cytoplasm Golgi apparatus centrosome Biological process endosome to lysosome transport endosome organization neuronal stem cell population maintenance Golgi localization early endosome to late endosome transport cytoplasmic microtubule organization protein transport lysosome organization microtubule anchoring at centrosome interkinetic nuclear migration negative regulation of neurogenesis protein localization to centrosome cytoskeleton-dependent intracellular transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84376 320191 Ensembl ENSG00000168172 ENSMUSG00000037234 UniProt Q86VS8 Q8BUK6 RefSeq (mRNA) NM_032410 NM_207659 RefSeq (protein) NP_115786 NP_997542 Location (UCSC) Chr 8: 42.9 – 43.03 Mb Chr 8: 26.51 – 26.61 Mb PubMed search [3] [4]
Wikidata
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Function

Hook proteins are cytosolic coiled coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.^[6]