HOXB1

Homeobox protein Hox-B1 is a protein that in humans is encoded by the HOXB1 gene.^[5][6][7]

HOXB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B72
Identifiers
Aliases	HOXB1, HCFP3, HOX2, HOX2I, Hox-2.9, homeobox B1
External IDs	OMIM: 142968; MGI: 96182; HomoloGene: 1615; GeneCards: HOXB1; OMA:HOXB1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.32 Start 48,528,526 bp[1] End 48,531,011 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 59.86 cM Start 96,256,578 bp[2] End 96,259,082 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney gonad human kidney renal cortex cervix fallopian tube urinary bladder right uterine tube olfactory zone of nasal mucosa zone of skin Top expressed in primitive streak tail of embryo embryo Ileal epithelium embryonic organizer embryo somite neuromere rhombomere pharynx More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding protein domain specific binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process multicellular organism development pattern specification process regulation of transcription, DNA-templated transcription, DNA-templated transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II anatomical structure morphogenesis anterior/posterior pattern specification rhombomere development rhombomere 4 development rhombomere 5 development facial nerve structural organization facial nucleus development anatomical structure formation involved in morphogenesis embryonic skeletal system morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3211 15407 Ensembl ENSG00000120094 ENSMUSG00000018973 UniProt P14653 P17919 RefSeq (mRNA) NM_002144 NM_008266 RefSeq (protein) NP_002135 NP_032292 Location (UCSC) Chr 17: 48.53 – 48.53 Mb Chr 11: 96.26 – 96.26 Mb PubMed search [3] [4]
Wikidata
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Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17.^[7]

Interactions

HOXB1 has been shown to interact with PBX1.^[8][9]

See also

• Tandemly arrayed genes