HOXB8

Homeobox protein Hox-B8 is a protein that in humans is encoded by the HOXB8 gene.^[5][6][7]

HOXB8
Identifiers
Aliases	HOXB8, HOX2, HOX2D, Hox-2.4, homeobox B8
External IDs	OMIM: 142963; MGI: 96189; HomoloGene: 7768; GeneCards: HOXB8; OMA:HOXB8 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.32 Start 48,611,377 bp[1] End 48,615,292 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 59.82 cM Start 96,172,731 bp[2] End 96,176,141 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis seminal vesicula C1 segment gonad human kidney mucosa of ileum mucosa of transverse colon right adrenal gland caput epididymis left adrenal cortex Top expressed in lumbar subsegment of spinal cord tail of embryo transitional epithelium of urinary bladder thoracic vertebral column paramesonephric duct paraxial mesoderm perirhinal cortex urethra motor neuron entorhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm Biological process embryonic skeletal system morphogenesis multicellular organism development adult locomotory behavior grooming behavior sensory perception of pain skeletal system morphogenesis dorsal spinal cord development regulation of transcription, DNA-templated negative regulation of myeloid cell differentiation transcription, DNA-templated anterior/posterior pattern specification negative regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3218 15416 Ensembl ENSG00000120068 ENSMUSG00000056648 UniProt P17481 P09632 RefSeq (mRNA) NM_024016 NM_010461 RefSeq (protein) NP_076921 NP_034591 Location (UCSC) Chr 17: 48.61 – 48.62 Mb Chr 11: 96.17 – 96.18 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of Homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog (see Homology (biology) § Orthology) of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the hair-pulling behavior of humans suffering from trichotillomania (TTM).^[7]

Transplantation of normal (wild-type) bone marrow into a Hoxb8 mutant mouse results in a reduction of compulsive grooming.^[8]

See also

• Homeobox