HOXB9

Homeobox protein Hox-B9 is a protein that in humans is encoded by the HOXB9 gene.^[5][6][7]

HOXB9
Identifiers
Aliases	HOXB9, HOX-2.5, HOX2, HOX2E, homeobox B9
External IDs	OMIM: 142964; MGI: 96190; HomoloGene: 7367; GeneCards: HOXB9; OMA:HOXB9 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.32 Start 48,621,156 bp[1] End 48,626,358 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 59.81 cM Start 96,162,283 bp[2] End 96,167,421 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon corpus epididymis rectum buccal mucosa cell mucosa of sigmoid colon caput epididymis gonad testicle mucosa of ileum human kidney Top expressed in tail of embryo lumbar subsegment of spinal cord somite adrenal gland genital tubercle urethra male urethra right kidney neural tube seminal vesicula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding protein binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus mitochondrion nucleoplasm RNA polymerase II transcription regulator complex Biological process cell chemotaxis canonical Wnt signaling pathway multicellular organism development regulation of transcription, DNA-templated transcription, DNA-templated anterior/posterior pattern specification positive regulation of transcription by RNA polymerase II embryonic skeletal system development mammary gland development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3219 15417 Ensembl ENSG00000170689 ENSMUSG00000020875 UniProt P17482 P20615 RefSeq (mRNA) NM_024017 NM_008270 RefSeq (protein) NP_076922 NP_032296 Location (UCSC) Chr 17: 48.62 – 48.63 Mb Chr 11: 96.16 – 96.17 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer.^[7]

Interactions

HOXB9 has been shown to interact with BTG2^[8] and BTG1.^[8]

See also

• Homeobox